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綜上所述，通過(guò)PEI示蹤染色對(duì)AN大鼠AS表達(dá)和分布的研究，證實(shí)了AN大鼠GBM上AS與蛋白尿之間的相關(guān)性。AS是GBM電荷屏障功能正常的重要標(biāo)志之一，祛風(fēng)通絡(luò)方可能通過(guò)改善AN大鼠GBM上HSPG的表達(dá)而改善AS的表達(dá)和分布，修復(fù)GBM電荷屏障，從而起到防治腎性蛋白尿的作用。但其影響基底膜相關(guān)蛋白之間的信號(hào)轉(zhuǎn)導(dǎo)以及內(nèi)在的調(diào)節(jié)機(jī)制還有待深入研究。
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