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醫(yī)學(xué)免費(fèi)論文:中性粒細(xì)胞/淋巴細(xì)胞比率對急性心肌梗死患者臨床并發(fā)癥的預(yù)測價(jià)值
【摘要】 目的： 探討中性粒細(xì)胞/淋巴細(xì)胞比率(NLR)與急性心肌梗死(AMI)患者臨床并發(fā)癥之間的關(guān)系。 方法： 入選急性ST段抬高心肌梗死(STEMI)患者218例,入院后即刻抽取靜脈血查血常規(guī),按中性粒細(xì)胞/淋巴細(xì)胞比率的大小由小到大將其分為A、B兩組,對兩組急性心肌梗死并發(fā)癥發(fā)生率進(jìn)行比較。 結(jié)果： 兩組肌鈣蛋白峰值分別為(32.5±21.7)ng/ml和(56.8±39.4)ng/ml,B組高于A組,差異具有統(tǒng)計(jì)學(xué)意義(P<0.01)。心律失常(17.43%和39.45%,P<0.01)、心力衰竭(22.94%和51.38%,P<0.01)及猝死發(fā)生率(2.75%和11.01%,P<0.05)B組均顯著高于A組,差異具有統(tǒng)計(jì)學(xué)意義。多元逐步回歸分析顯示NLR與AMI并發(fā)癥發(fā)生率具有顯著的相關(guān)性(P<0.05)。結(jié)論： 中性粒細(xì)胞/淋巴細(xì)胞比率是急性心肌梗死患者臨床并發(fā)癥的可靠預(yù)測指標(biāo)。
【關(guān)鍵詞】 中性粒細(xì)胞/淋巴細(xì)胞比率; 急性心肌梗死; 臨床并發(fā)癥; 預(yù)后
Usefulness of the neutrophil to lymphocyte ratio in predicting complications
in patients with acute myocardial infarction
LU Yi1, FU Qiang2, LIU Yi2, SHENG Yang1, WEI Peng1
(1. School of Medicine, Jiangsu University, Zhenjiang Jiangsu 212013; 2.Department of Cardiology, the Central Hospital of Xuzhou, Xuzhou Jiangsu 221009, China)
[Abstract] Objective: To investigate the relationship between the neutrophil to lymphocyte ratio and the morbidity of AMI complications. Methods： A total of 218 patients with ST segment elevated myocardial infarction whose blood routines were obtained at the admission were studied. All cases were divided into two groups according to the neuropil to lymphocyte ratio of small to large size. Then we analyzed the morbidity of AMI complications between the two groups. Results： The peak value of cardiac troponin I was higher in group B[(32.5±21.7) ng/ml and (56.8±39.4) ng/ml respectively, P<0.01]. The incidences of arrhythmia (17.43% and 39.45%,P<0.01), heart failure (22.94% and 51.38%,P<0.01) and death (2.75% and 11.01%,P<0.05) were also higher in group B. The multivariate stepwise regression analysis showed that the neutrophil to lymphocyte ratio and the morbidity of AMI complications had significant correlation. Conclusion： The neutrophil to lymphocyte ratio was a reliable indicator that can predict morbidity of AMI complications醫(yī).學(xué).全.在.線bhskgw.cn.
[Key words] neutrophil to lymphocyte ratio; acute myocardial infarction; complication; prognosis
大量研究表明,動脈粥樣硬化是一種復(fù)雜的,與多種因素有關(guān)的疾病。炎癥反應(yīng)在此過程中具有重要的作用。許多不同的炎癥指標(biāo),如C反應(yīng)蛋白、白細(xì)胞等,被認(rèn)為是上述疾病過程重要的生物學(xué)標(biāo)志物。近年來,對白細(xì)胞分類計(jì)數(shù)的研究越來越多。研究顯示[1],中性粒細(xì)胞/淋巴細(xì)胞比率(NLR)對急性冠脈綜合征(acute coronary syndrome, ACS) 診斷及預(yù)后具有重要價(jià)值。國內(nèi)關(guān)于中性粒細(xì)胞/淋巴細(xì)胞比率與急性心肌梗死(acute myocardial infarction, AMI)預(yù)后的研究尚少。本研究旨在探討中性粒細(xì)胞/淋巴細(xì)胞比率與急性心肌梗死患者臨床并發(fā)癥之間的關(guān)系。
