1.HonganB,Costantini F,Lacy L,et al.Manipulating the mouse embryo-A Lab Manual ColdSping Harbor NY:Cold Spring Harbor Lab,1986,332-340
2.琦祖和，轉(zhuǎn)基因動(dòng)物技術(shù)，中華病理學(xué)雜志，1993，22：375
3.GordonJW ,Scangos GA,Plotdin DJ,et al Genetic transformation of mouse embryos byonicroinjection of purified DNA,Proc Natl Acad Sci USA,1980,77:7380
4.鄢盛愷，載鬲蛋白轉(zhuǎn)基因小鼠的研究進(jìn)展，國外醫(yī)學(xué)臨床生化化學(xué)家與檢驗(yàn)分冊，1996
5.BreslowJL,Transgenic mouse models of lipoprotein metabolism and atherosclerosis ProcNatl Acad Sci USA,1993,90:8314
6.BreslowJL,Insight into liporotein metabolism from studies in transgenic mince .Ann RevPhysid ,1994,56:797
7.何泉，王芳菲，陳蘭英，心血管疾病轉(zhuǎn)基因動(dòng)物模型的建立，高血壓雜志，1996，4：76
8.BrinsterRL,Chen HY ,Trwmbaaer ME,et al Factors affecting the efficency of introducingforewww.med126.comign DNA into mice by microinjecting eggs Proc Natl Aead SciUSA,1985,82:4438
9.EngerP,Haasch D,Pinkert CA,et al A strain-specific modifier on morse chromosome4controls the methyla tion of independent transgene loci,Cell,1991,65:9393
10.EricksonRP,Why isn"t a mouse more like a man?Trends Gen ,1989,5:1
11.PalmeterRD,Brinster RL,Hammer RE,et al Dramatic growth of mice that develop from eggsmicrojected with metallothinonein-growth lwrmone fusion germets ,Nature,1982,1300:611
12.胡以平，轉(zhuǎn)基因小鼠一生命科學(xué)研究的新體系，自然雜志，1990，13：28
13.PiedrahitaJA,Zhang SH,Hagaman JR et al Generation of mice corrging a mutantapolipoprotein E gene inacfivated by gene targeting in embryowww.med126.comnic cells ProcNatl Acad Sci USA,1992,13:28
14.陳保生，載脂蛋白基因異常表達(dá)引起的高脂血癥和動(dòng)脈粥硬化及轉(zhuǎn)基因技術(shù)在研究心血管疾病中的意義，中國循環(huán)雜志，1995，10：65
15.劉德培，方福德，梁植權(quán)，基因剔除，生理科學(xué)進(jìn)展，1995，26：88
16.MansourSL,Thomas KR,Capecchi MR,Dsiruption of the proto oncogene int 2 in mouse embryoderived stem cells a general strategty for targeting mutations tonon-selectable genes ,Narure ,1988,336:348
17.PlumpSA,Smith JD,Hayek T,et al Severe hypercholesterolemia and atherosclerosis inapolipoprotein E-deficient mice created by homologous recombination in ES cellscell,1992,71:343
18.SauerB,Henderson N,Site specific DNA reambinaton in mammalian cells by the Crerecombinsae of bacteriophage P1,Proc Natl Acad Sci USA,1988,85:5166
19.CuH,Marth JD,Orban PC,et al.Deletion of a DNA polymerase βgene segment in Tcellsusing cell type specific gene targeting Scince,1994,265:103
20.RubinE,M,Kraurs R,M,Spangler E,A et al Inhibition of carly atherogenesis intransgenic mice by human apolipoprotein A I ,Nature ,1991,353:265
21.HayekT,Ito Y,Azrolan N,et al Dietray fat increases high denritylipoprotein(HDL)levels both by increasing the rtansport rates and decreasingthe fractional catabolic rates of HDL cholesterol ester and apolipoprotein(Apo)A I presentation of a new animal model and mechanistic studies in humanApoA I transgenic and control mice .J Clin Invest ,1993,91:1665
22.HayekT,C hajek-Shaul T,Walsh A,et al Probucol decreases allipoprotein A I tranrportrate and incresaes high density lipoprotein cholesteryl ester fractionalcatabolic rate in control and human apolipoprotein A I transgenic mice,Arterioscler Thromb,1991,11:1295
23.WilliamosnR,Lee D,Hegaman,Jet al Marked reduction of high denrity lipoprotein cholesterolin mice genetically modofice to lack apolipoprotein A I Proc Natl Acad SciUSA,1992,89:7234
24.ShultzJR ,Gong EL,McCall MR,et al.Expression of human apolipoprotein A-Ⅱand its effect on high density kliporoteins in tranrgenic mice ,JBiol Chem,1992,267:21630
25.SchultzJ,R,Verstryft J,Gong E L,et al Protein compositoin determines theanti-atherogenic properties of high densicty lipoproteins in transgenic miceNature ,1993,365:761
26.LintonMF ,Farese RV Jr,Chiesa G,et al.Transgenic mice ezpressing high plarmaconcentrations of human apolipoprotein B and lipoprotein(a),JclinInvest,1993,92:3029
27.CallowMJ,Stoltzfus LJ,Lawn RM,et al Expression of human apolipoprotein B and assemblyof lipoprotein (a)in transgenic mice Proc Natl Acad Sci USA,1994,92:21130
28.ItoY,Azrolan N,O Connell A,et al ,Hypertriglyceridermia as a result of humanapolipoprotein C-Ⅲgeneexpression in transgenic mice ,Science,1990,249:790
29,AaltSetala K,Fisher EA,Chen X,et al Mechanism of hypertriglycerdemia in humanapolipoprotein (Apo)CⅢ transgenicmice dimished very low density lipoprotein frctional catalbolic rate associatedwith increased ApocⅢ and reducedApoe on the partides J clin Invest,1992,90:1889
30.ShimanoH,Yamada N,Katsuki M,et al .Plasma lipoprotein metabolism in transgenic miceoverczpressing apolipoprotein E accelerated clearace of lipoproteins containingapolipoprotein B J Clin Invest,1992,90:2084
31.PasztyC,Macda N,Verstuylt,J,et al.Apolipoprotein A-i transgene corrects apolipoprteinE defieiency-induced atherosclerosis in nice ,j Clin Invest,1994,93:3301
32.ChiesaC,Hobbs HH,Koschinsky ML,et al Reconstitution of lipoprotein(a)by infusion ofhuman low density lipoprotein into transgeinc mice expressing humanapolipoprotein(a),J Biol Chem,1992,267:24369
33.LiuAC .Lawn RM,Verstugft JC,et al Human apolipoprotein A-I preventsatherosclerosis associated with apolipoprotein (a) in transgenic mice ,J LipidRes,1994,35:2263
34.AllisonJ,Campbell IL,Morahan Get al Diabetes in transgenic mice resulting fromnover-expression of classl histocompatibility molecules in pancreatinβcells,Nature ,1988,333:529
35.MarbanSL,Deloia JA,Gearhart JD,et la.Hyperinsulinemia in transgenic mice carryingmutiple copies of the human insuline gene,Dev Genet,1989
36.MackayK,Stnkert JL,Pinkert CA,et al.Glomeralosclerosis and renal cysts in micetransgenic for the early region of SV,Kidney Int ,1987,32:827
37.DoiT,Striker LJ,Quife C,et al Progressive glomeruloscleroxis develops inrtansgenic mice chronically ezpressing growth hormone and growth hormonereleasing factor but not in those expressing insulintide growth factor-1,Am J
